Evaluating multiple surrogate markers with censored data.

ABSTRACT: The utilization of surrogate markers offers the opportunity to reduce the length of required follow-up time and/or costs of a randomized trial examining the effectiveness of an intervention or treatment. There are many available methods for evaluating the utility of a single surrogate marker including both parametric and nonparametric approaches. However, as the dimension of the surrogate marker increases, a completely nonparametric procedure becomes infeasible due to the curse of dimensionality. In this paper, we define a quantity to assess the value of multiple surrogate markers in a time-to-event outcome setting and propose a robust estimation approach for censored data. We focus on surrogate markers that are measured at some landmark time, t₀ , which occurs earlier than the

SUBMITTER: Parast L 

PROVIDER: S-EPMC8162900 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature