Ontology highlight
ABSTRACT:
SUBMITTER: Fuse H
PROVIDER: S-EPMC8163015 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Chemical science 20201012 44
Hydroxyalkylation of <i>N</i>-heteroaromatics with aldehydes was achieved using a binary hybrid catalyst system comprising an acridinium photoredox catalyst and a thiophosphoric acid organocatalyst. The reaction proceeded through the following sequence: (1) photoredox-catalyzed single-electron oxidation of a thiophosphoric acid catalyst to generate a thiyl radical, (2) cleavage of the formyl C-H bond of the aldehyde substrates by a thiyl radical acting as a hydrogen atom transfer catalyst to gen ...[more]