Atomistic fibrillar architectures of polar prion-inspired heptapeptides.

ABSTRACT: This article provides the computational prediction of the atomistic architectures resulting from self-assembly of the polar heptapeptide sequences NYNYNYN, SYSYSYS and GYGYGYG. Using a combination of molecular dynamics and a newly developed tool for non-covalent interaction analysis, we uncover the properties of a new class of bionanomaterials, including hydrogen-bonded polar zippers, and the relationship between peptide composition, fibril geometry and weak interaction networks. Our results, corroborated by experimental observations, provide the basis for the rational design of prion-inspired nanomaterials.

SUBMITTER: Peccati F 

PROVIDER: S-EPMC8163036 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature