Phloretin, an Apple Polyphenol, Inhibits Pathogen-Induced Mucin Overproduction.

ABSTRACT:

Scope

Bacterial infection induces mucus overproduction, contributing to acute exacerbations and lung function decline in chronic respiratory diseases. A diet enriched in apples may provide protection from pulmonary disease development and progression. This study examined whether phloretin, an apple polyphenol, inhibits mucus synthesis and secretion induced by the predominant bacteria associated with chronic respiratory diseases.

Methods and results

The expression of mucus constituent mucin 5AC (MUC5AC) in FVB/NJ mice and NCI-H292 epithelial cells is analyzed. Nontypeable Haemophilus influenzae (NTHi)-infected mice developed increased MUC5AC mRNA, which a diet containing phloretin inhibited. In NCI-H292 cells, NTHi, Moraxella catarrhalis, Streptococcus pneumoniae, and Pseudom

SUBMITTER: Birru RL 

PROVIDER: S-EPMC8163070 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature