Plasma amino acid concentrations during experimental hyperinsulinemia in 2 laminitis models.

ABSTRACT:

Background

Endocrinopathic laminitis develops in association with insulin dysregulation, but the role of insulin in the pathogenesis remains unclear. Hyperinsulinemia can cause hypoaminoacidemia, which is associated with integumentary lesions in other species and therefore warrants investigation as a potential mechanism in laminitis.

Objective

Evaluate plasma amino acid concentrations in the euglycemic-hyperinsulinemic clamp (EHC) and prolonged glucose infusion (PGI) laminitis models.

Animals

Sixteen Standardbred horses.

Methods

Prospective experimental study. Plasma amino acid concentrations were measured in samples collected every 6 hours from horses that underwent a 48-hour EHC (n = 8) or 66-hour PGI (n = 8) after a 24- or 6-hour baseline period in EHC and P

SUBMITTER: Stokes SM 

PROVIDER: S-EPMC8163125 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature