Nickel-catalyzed three-component olefin reductive dicarbofunctionalization to access alkylborates.

ABSTRACT: We report a three-component olefin reductive dicarbofunctionalization for constructing alkylborates, specifically, nickel-catalyzed reductive dialkylation and alkylarylation of vinyl boronates with a variety of alkyl bromides and aryl iodides. This reaction exhibits good coupling efficiency and excellent functional group compatibility, providing convenient access to the late-stage modification of complex natural products and drug molecules. Combined with alkylborate transformations, this reaction could also find applications in the modular and convergent synthesis of complex compounds.

SUBMITTER: Wang XX 

PROVIDER: S-EPMC8163243 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature