AIE-based nanoaggregate tracker: high-fidelity visualization of lysosomal movement and drug-escaping processes.

ABSTRACT: High-fidelity imaging and long-term visualization of lysosomes are crucial for their functional evaluation, related disease detection and active drug screening. However, commercial aggregation-caused quenching probes are not conducive to precise lysosomal imaging because of their inherent drawbacks, like easy diffusion, short emission and small Stokes shift, let alone their long-term tracing due to rapid photobleaching. Herein we report a novel aggregation-induced emission (AIE)-based TCM-PI nanoaggregate tracker for direct visualization of lysosomes based on the building block of tricyano-methylene-pyridine (TCM), wherein introduced piperazine (PI) groups behave as targeting units to lysosomes upon protonation, and the self-assembled nanostructure contributes to fast endocytosis for enhan

SUBMITTER: Liu Z 

PROVIDER: S-EPMC8163247 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature