A critical analysis of electrospray techniques for the determination of accelerated rates and mechanisms of chemical reactions in droplets.

ABSTRACT: Electrospray and Electrosonic Spray Ionization Mass Spectrometry (ESI-MS and ESSI-MS) have been widely used to report evidence that many chemical reactions in micro- and nano-droplets are dramatically accelerated by factors of ∼10² to 10⁶ relative to macroscale bulk solutions. Despite electrospray's relative simplicity to both generate and detect reaction products in charged droplets using mass spectrometry, substantial complexity exists in how the electrospray process itself impacts the interpretation of the mechanism of these observed accelerated rates. ESI and ESSI are both coupled multi-phase processes, in which analytes in small charged droplets are transferred and detected as gas-phase ions with a mass spectrometer. As such, quantitative examination is needed to

SUBMITTER: Rovelli G 

PROVIDER: S-EPMC8163298 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature