Synthesis of unsymmetrical sulfamides and polysulfamides via SuFEx click chemistry.

ABSTRACT: As hydrogen-bond donors and acceptors, N,N'-disubstituted sulfamides have been used in a range of applications from medicinal chemistry to anion-binding catalysis. However, compared to ureas or thioureas, the utilization of this unique moiety remains marginal, in part because of a lack of general synthetic methods to access unsymmetrical sulfamides. Specifically, polysulfamides are a virtually unknown type of polymer despite their potential utility in non-covalent dynamic networks, an intense area of research in materials science. We report herein a practical and efficient process to prepare unsymmetrical sulfamides via Sulfur(vi)-Fluoride Exchange (SuFEx) click chemistry. This process was then applied to synthesize polysulfamides. Thermal analysis showed that this fam

SUBMITTER: Kulow RW 

PROVIDER: S-EPMC8163303 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature