Pinkment: a synthetic platform for the development of fluorescent probes for diagnostic and theranostic applications.

ABSTRACT: Reaction-based fluorescent-probes have proven successful for the visualisation of biological species in various cellular processes. Unfortunately, in order to tailor the design of a fluorescent probe to a specific application (i.e. organelle targeting, material and theranostic applications) often requires extensive synthetic efforts and the synthetic screening of a range of fluorophores to match the required synthetic needs. In this work, we have identified Pinkment-OH as a unique "plug-and-play" synthetic platform that can be used to develop a range of ONOO^- responsive fluorescent probes for a variety of applications. These include theranostic-based applications and potential material-based/bioconjugation applications. The as prepared probes displayed an excellent

SUBMITTER: Weber M 

PROVIDER: S-EPMC8163375 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature