Chronic perinatal hypoxia delays cardiac maturation in a mouse model for cyanotic congenital heart disease.

ABSTRACT: Compared with acyanotic congenital heart disease (CHD), cyanotic CHD has an increased risk of lifelong mortality and morbidity. These adverse outcomes may be attributed to delayed cardiomyocyte maturation, since the transition from a hypoxic fetal milieu to oxygen-rich postnatal environment is disrupted. We established a rodent model to replicate hypoxic myocardial conditions spanning perinatal development, and tested the hypothesis that chronic hypoxia impairs cardiac development. Pregnant mice were housed in hypoxia beginning at embryonic day 16. Pups stayed in hypoxia until postnatal day (P)8 when cardiac development is nearly complete. Global gene expression was quantified at P8 and at P30, after recovering in normoxia. Phenotypic testing inclu

SUBMITTER: Romanowicz J 

PROVIDER: S-EPMC8163656 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature