Mitochondrial contributions to vascular endothelial dysfunction, arterial stiffness, and cardiovascular diseases.

ABSTRACT: Cardiovascular disease (CVD) affects one in three adults and remains the leading cause of death in America. Advancing age is a major risk factor for CVD. Recent plateaus in CVD-related mortality rates in high-income countries after decades of decline highlight a critical need to identify novel therapeutic targets and strategies to mitigate and manage the risk of CVD development and progression. Vascular dysfunction, characterized by endothelial dysfunction and large elastic artery stiffening, is independently associated with an increased CVD risk and incidence and is therefore an attractive target for CVD prevention and management. Vascular mitochondria have emerged as an important player in maintaining vascular homeostasis. As such, age- and disease-related impairments in mitochondrial fu

SUBMITTER: Kirkman DL 

PROVIDER: S-EPMC8163660 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature