Differences Between Familial and Sporadic Celiac Disease.

ABSTRACT:

Background

It is not known if genetic background, characteristics at diagnosis, physical and psychological well-being, and adherence to a gluten-free diet are comparable between patients with familial or sporadic celiac disease. These issues were investigated in a follow-up study.

Methods

Altogether 1064 patients were analyzed for celiac disease-associated serology, predisposing HLA-DQ, and non-HLA genotypes. Medical data were collected from patient records and supplementary interviews. Current symptoms and quality of life were further evaluated with the Gastrointestinal Symptom Rating Scale (GSRS), the Psychological General Well-Being questionnaire (PGWB), and Short Form 36 (SF-36) questionnaires.

Results

Familial and sporadic groups differed (P < 0.001) in the reaso

SUBMITTER: Airaksinen L 

PROVIDER: S-EPMC8163668 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature