Progressive deterioration of the upper respiratory tract and the gut microbiomes in children during the early infection stages of COVID-19.

ABSTRACT: Children are less susceptible to coronavirus disease 2019 (COVID-19), and they have manifested lower morbidity and mortality after infection, for which a multitude of mechanisms may be considered. Whether the normal development of the gut-airway microbiome in children is affected by COVID-19 has not been evaluated. Here, we demonstrate that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection alters the upper respiratory tract and the gut microbiomes in nine children. The alteration of the microbiome is dominated by the genus Pseudomonas, and it sustains for up to 25-58 days in different individuals. Moreover, the patterns of alternation are different between the upper respiratory tract and the gut. Longitudinal investigation shows that the upper respiratory tract and the

SUBMITTER: Xu R 

PROVIDER: S-EPMC8163695 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature