The ALDOA Metabolism Pathway as a Potential Target for Regulation of Prostate Cancer Proliferation.

ABSTRACT:

Background

ALDOA plays an essential role in cancer progression in different human cancers; however, its function has not been understood in prostate cancer (PCa).

Methods

Associations of ALDOA expression with clinicopathological features and patient prognosis in PCa were evaluated based on data obtained from the Taylor database and our clinical tissue microarray. The potential roles of ALDOA in malignant progression were verified using a series of in vivo and in vitro experiments after stable ALDOA overexpression and knockdown in DU145 and PC3 cell lines. An aldolase A inhibitor was used to determine the effects of inhibition of ALDOA on PCa cell proliferation.

Results

Higher expression of ALDOA was positively correlated with the incidence of postoperative metastasis

SUBMITTER: Kuang Q 

PROVIDER: S-EPMC8163754 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature