Ontology highlight
ABSTRACT:
SUBMITTER: Peneder P
PROVIDER: S-EPMC8163828 | biostudies-literature | 2021 May
REPOSITORIES: biostudies-literature
Peneder Peter P Stütz Adrian M AM Surdez Didier D Krumbholz Manuela M Semper Sabine S Chicard Mathieu M Sheffield Nathan C NC Pierron Gaelle G Lapouble Eve E Tötzl Marcus M Ergüner Bekir B Barreca Daniele D Rendeiro André F AF Agaimy Abbas A Boztug Heidrun H Engstler Gernot G Dworzak Michael M Bernkopf Marie M Taschner-Mandl Sabine S Ambros Inge M IM Myklebost Ola O Marec-Bérard Perrine P Burchill Susan Ann SA Brennan Bernadette B Strauss Sandra J SJ Whelan Jeremy J Schleiermacher Gudrun G Schaefer Christiane C Dirksen Uta U Hutter Caroline C Boye Kjetil K Ambros Peter F PF Delattre Olivier O Metzler Markus M Bock Christoph C Tomazou Eleni M EM
Nature communications 20210528 1
Sequencing of cell-free DNA in the blood of cancer patients (liquid biopsy) provides attractive opportunities for early diagnosis, assessment of treatment response, and minimally invasive disease monitoring. To unlock liquid biopsy analysis for pediatric tumors with few genetic aberrations, we introduce an integrated genetic/epigenetic analysis method and demonstrate its utility on 241 deep whole-genome sequencing profiles of 95 patients with Ewing sarcoma and 31 patients with other pediatric sa ...[more]