Network topology changes in chronic mild traumatic brain injury (mTBI).

ABSTRACT:

Background

In mild traumatic brain injury (mTBI), diffuse axonal injury results in disruption of functional networks in the brain and is thought to be a major contributor to cognitive dysfunction even years after trauma.

Objective

Few studies have assessed longitudinal changes in network topology in chronic mTBI. We utilized a graph theoretical approach to investigate alterations in global network topology based on resting-state functional connectivity in veterans with chronic mTBI.

Methods

50 veterans with chronic mTBI (mean of 20.7 yrs. from trauma) and 40 age-matched controls underwent two functional magnetic resonance imaging scans 18 months apart. Graph theory analysis was used to quantify network topology measures (density, clustering coefficient, global efficie

SUBMITTER: Boroda E 

PROVIDER: S-EPMC8163989 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature