Cellular senescence as a driver of cognitive decline triggered by chronic unpredictable stress.

ABSTRACT: When an individual is under stress, the undesired effect on the brain often exceeds expectations. Additionally, when stress persists for a long time, it can trigger serious health problems, particularly depression. Recent studies have revealed that depressed patients have a higher rate of brain aging than healthy subjects and that depression increases dementia risk later in life. However, it remains unknown which factors are involved in brain aging triggered by chronic stress. The most critical change during brain aging is the decline in cognitive function. In addition, cellular senescence is a stable state of cell cycle arrest that occurs because of damage and/or stress and is considered a sign of aging. We used the chronic unpredictable stress (CUS) model to mimic stressful life situatio

SUBMITTER: Lin YF 

PROVIDER: S-EPMC8163993 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature