Tolerance to nascent protein misfolding stress requires fine-tuning of the cAMP/PKA pathway.

ABSTRACT: Protein aggregation is the abnormal association of misfolded proteins into larger, often insoluble structures that can be toxic during aging and in protein aggregation-associated diseases. Previous research has established a role for the cytosolic Tsa1 peroxiredoxin in responding to protein misfolding stress. Tsa1 is also known to downregulate the cAMP/protein kinase A (PKA) pathway as part of the response to hydrogen peroxide stress. However, whether the cAMP/PKA pathway is involved in protein misfolding stress is not known. Using transcriptomics, we examined the response to protein misfolding stress and found upregulation of numerous stress gene functions and downregulation of many genes related to protein synthesis and other growth-related processes consistent with the well-characterize

SUBMITTER: Kritsiligkou P 

PROVIDER: S-EPMC8164027 | biostudies-literature | 2021 Jan-Jun

REPOSITORIES: biostudies-literature