Dysregulation of COVID-19 related gene expression in the COPD lung.

ABSTRACT:

Background

Chronic obstructive pulmonary disease (COPD) patients are at increased risk of poor outcome from Coronavirus disease (COVID-19). Early data suggest elevated Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) receptor angiotensin converting enzyme 2 (ACE2) expression, but relationships to disease phenotype and downstream regulators of inflammation in the Renin-Angiotensin system (RAS) are unknown. We aimed to determine the relationship between RAS gene expression relevant to SARS-CoV-2 infection in the lung with disease characteristics in COPD, and the regulation of newly identified SARS-CoV-2 receptors and spike-cleaving proteases, important for SARS-CoV-2 infection.

Methods

We quantified gene expression using RNA sequencing of epithelial brushings and b

SUBMITTER: Watson A 

PROVIDER: S-EPMC8164067 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature