Molecular mechanisms of Zika virus teratogenesis from animal studies: a systematic review protocol.

ABSTRACT:

Background

Due to the diversity of studies in animal models reporting that molecular mechanisms are involved in the teratogenic effect of the Zika virus (ZIKV), the objective of the present study is to evaluate the methodological quality of these studies, as well as to demonstrate which genes and which molecular pathways are affected by ZIKV in different animal models.

Methods

This search will be performed in four databases: PubMed/MEDLINE, EMBASE, Web of Science, and Scopus, as well as in the grey literature. The studies selection process will be reported through the PRISMA Statement diagram model. All studies describing the molecular mechanisms possibly involved in the development of malformations caused by embryonic/fetal ZIKV exposure in animal models with an appropriate

SUBMITTER: Wachholz GE 

PROVIDER: S-EPMC8164069 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature