The association between obesity and weight loss after bariatric surgery on the vaginal microbiota.

ABSTRACT:

Background

Obesity and vaginal microbiome (VMB) dysbiosis are each risk factors for adverse reproductive and oncological health outcomes in women. Here, we investigated the relationship between obesity, vaginal bacterial composition, local inflammation and bariatric surgery.

Methods

Vaginal bacterial composition assessed by high-throughput sequencing of bacterial 16S rRNA genes and local cytokine levels measured using a multiplexed Magnetic Luminex Screening Assay were compared between 67 obese and 42 non-obese women. We further assessed temporal changes in the microbiota and cytokines in a subset of 27 women who underwent bariatric surgery.

Results

The bacterial component of the vaginal microbiota in obese women was characterised by a lower prevalence of a Lactobacil

SUBMITTER: Raglan O 

PROVIDER: S-EPMC8164250 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature