Deep exploration of PARP inhibitors in breast cancer: monotherapy and combination therapy.

ABSTRACT:

Objective

Nearly 5% of patients with breast cancer carry germline BRCA mutations, which are more common in triple-negative breast cancer (TNBC). Previous clinical trials demonstrated the therapeutic efficacy of poly (ADP-ribose) polymerase inhibitors (PARPis) against BRCA-mutated metastatic breast cancer. The current study conducted a systemic review and meta-analysis of the clinical efficiency and safety of PARPis, either alone or combined with chemotherapy, in patients with TNBC.

Methods

We searched PubMed, EMBASE, and ClinicalTrials.gov to identify randomized controlled trials comparing PARPi therapy with chemotherapy, and comparisons of chemotherapy plus PARPis with chemotherapy alone were included. The study endpoints included the clinical response, progre

SUBMITTER: Chen Z 

PROVIDER: S-EPMC8164563 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature