The role of HCO₃^- in propionate-induced anion secretion across rat caecal epithelium.

ABSTRACT: Propionate, a metabolite from the microbial fermentation of carbohydrates, evokes a release of epithelial acetylcholine in rat caecum resulting in an increase of short-circuit current (I_sc) in Ussing chamber experiments. The present experiments were performed in order to characterize the ionic mechanisms underlying this response which has been thought to be due to Cl^- secretion. As there are regional differences within the caecal epithelium, the experiments were conducted at oral and aboral rat corpus caeci. In both caecal segments, the propionate-induced I_sc (I_Prop) was inhibited by > 85%, when the experiments were performed either in nominally Cl^-- or nominally HCO₃^--free buffer. In the case of Cl^-, t

SUBMITTER: Ballout J 

PROVIDER: S-EPMC8164622 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature