Prognostic impact of the glypican family of heparan sulfate proteoglycans on the survival of breast cancer patients.

ABSTRACT:

Purpose

Dysregulated expression of proteoglycans influences the outcome and progression of numerous cancers. Several studies have investigated the role of individual glypicans in cancer, however, the impact of the whole glypican family of heparan sulfate proteoglycans on prognosis of a large patient cohort of breast cancer patients has not yet been investigated. In the present study, our aim was to investigate the prognostic power of the glypicans in breast cancer patients.

Methods

We used a public database including both gene expression data and survival information for 3951 breast cancer patients to determine the prognostic value of glypicans on relapse-free survival using Cox regression analysis. Moreover, we performed quantitative Real-Time PCR to determine glypican gene

SUBMITTER: Grillo PK 

PROVIDER: S-EPMC8164625 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature