Effects of indacaterol on the LPS-evoked changes in fluid secretion rate and pH in swine tracheal membrane.

ABSTRACT: An acquired dysregulation of airway secretion is likely involved in the pathophysiology of chronic bronchitis and chronic obstructive pulmonary disease (COPD). Nowadays, it is widely known that several kinds of long-acting bronchodilators reduce the frequency of COPD exacerbations. However, limited data are available concerning the complementary additive effects on airflow obstruction. Using an optical method and a selective pH indicator, we succeeded in evaluating the gland secretion rate and the pH in swine tracheal membrane. A physiologically relevant concentration of acetylcholine (ACh) 100 nM induced a gradual increase in the amount of gland secretion. Lipopolysaccharides (LPS) accelerated the ACh-induced secretory responses up to around threefold and lowered the pH level significantl

SUBMITTER: Aritake H 

PROVIDER: S-EPMC8164627 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature