Sex difference in the association between plasma selenium and first stroke: a community-based nested case-control study.

ABSTRACT:

Background

To date, there is no clearly defined association between plasma selenium levels and first stroke. We aimed to investigate the association between baseline plasma selenium and first stroke risk in a community-based Chinese population.

Methods

Using a nested case-control study design, a total of 1255 first stroke cases and 1255 matched controls were analyzed. Participant plasma selenium concentrations were measured by inductively coupled plasma mass spectrometry (ICP-MS), and the association of plasma selenium with first stroke risk was estimated by conditional logistic regression models.

Results

Overall, a non-linear negative association between plasma selenium and first total stroke and first ischemic stroke risks was found in males but not in females. Comp

SUBMITTER: Hu H 

PROVIDER: S-EPMC8164764 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature