Current understanding of epigenetics mechanism as a novel target in reducing cancer stem cells resistance.

ABSTRACT: At present, after extensive studies in the field of cancer, cancer stem cells (CSCs) have been proposed as a major factor in tumor initiation, progression, metastasis, and recurrence. CSCs are a subpopulation of bulk tumors, with stem cell-like properties and tumorigenic capabilities, having the abilities of self-renewal and differentiation, thereby being able to generate heterogeneous lineages of cancer cells and lead to resistance toward anti-tumor treatments. Highly resistant to conventional chemo- and radiotherapy, CSCs have heterogeneity and can migrate to different organs and metastasize. Recent studies have demonstrated that the population of CSCs and the progression of cancer are increased by the deregulation of different epigenetic pathways having effects on gene expression patter

SUBMITTER: Keyvani-Ghamsari S 

PROVIDER: S-EPMC8164819 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature