Neural correlates of fat preference in frontotemporal dementia: translating insights from the obesity literature.

ABSTRACT:

Objective

Alterations in eating behaviour are one of the diagnostic features of behavioural variant frontotemporal dementia (bvFTD). It is hypothesised that underlying brain network disturbances and atrophy to key structures may affect macronutrient preference in bvFTD. We aimed to establish whether a preference for dietary fat exists in bvFTD, its association with cognitive symptoms and the underlying neural mechanisms driving these changes.

Methods

Using a test meal paradigm, adapted from the obesity literature, with variable fat content (low 20%, medium 40% and high 60%), preference for fat in 20 bvFTD was compared to 16 Alzheimer's disease (AD) and 13 control participants. MRI brain scans were analysed to determine the neural correlates of fat preference.

Results

SUBMITTER: Ahmed RM 

PROVIDER: S-EPMC8164857 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature