Selective vulnerability to atrophy in sporadic Creutzfeldt-Jakob disease.

ABSTRACT:

Objective

Identification of brain regions susceptible to quantifiable atrophy in sporadic Creutzfeldt-Jakob disease (sCJD) should allow for improved understanding of disease pathophysiology and development of structural biomarkers that might be useful in future treatment trials. Although brain atrophy is not usually present by visual assessment of MRIs in sCJD, we assessed whether using voxel-based morphometry (VBM) can detect group-wise brain atrophy in sCJD.

Methods

3T brain MRI data were analyzed with VBM in 22 sCJD participants and 26 age-matched controls. Analyses included relationships of regional brain volumes with major clinical variables and dichotomization of the cohort according to expected disease duration based on prion molecular classification (i.e., short-dura

SUBMITTER: Younes K 

PROVIDER: S-EPMC8164858 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature