Assessing public perception of a sand fly biting study on the pathway to a controlled human infection model for cutaneous leishmaniasis.

ABSTRACT:

Background

A controlled human infection model (CHIM) involves deliberate exposure of volunteers to pathogens to assess their response to new therapies at an early stage of development. We show here how we used public involvement to help shape the design of a CHIM to support future testing of candidate vaccines for the neglected tropical disease cutaneous leishmaniasis, a disease transmitted by the bite of infected sand flies in tropical regions.

Methods

We undertook a public involvement (PI) consultation exercise to inform development of a study to test the safety and effectiveness of a sand fly biting protocol using uninfected sand flies (FLYBITE: ClinicalTrials.gov ID NCT03999970 ) and a CHIM using Leishmania major-infected sand flies (LEISH_Challenge: ClinicalTrials.gov I

SUBMITTER: Parkash V 

PROVIDER: S-EPMC8164890 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature