Modulating T Follicular Cells In Vivo Enhances Antigen-Specific Humoral Immunity.

ABSTRACT: Generation of high-affinity IgG is essential for defense against infections and cancer, which is the intended consequence of many vaccines, but can cause autoimmune and inflammatory diseases when inappropriately directed against self. The interplay of T follicular helper (T_FH) cells and T follicular regulatory (T_FR) cells is critical for the production of high-affinity IgG of a specific subclass. In this study, we sought to improve Ag-specific IgG responses with two interventions intended to transiently diminish T_FR cell influence. First, adult mice were administered an antibiotic mixture (ABX) for an extended period to deplete the immunoregulatory intestinal microbiota. This intriguingly increased T_FH cell and reduced T_FR cell numbers

SUBMITTER: Pagan JD 

PROVIDER: S-EPMC8164984 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature