Upregulation of eIF4E, but not other translation initiation factors, in dendritic spines during memory formation.

ABSTRACT: Local translation can provide a rapid, spatially targeted supply of new proteins in distal dendrites to support synaptic changes that underlie learning. Learning and memory are especially sensitive to manipulations of translational control mechanisms, particularly those that target the initiation step, and translation initiation at synapses could be a means of maintaining synapse specificity during plasticity. Initiation predominantly occurs via recruitment of ribosomes to the 5' mRNA cap by complexes of eukaryotic initiation factors (eIFs), and the interaction between eIF4E and eIF4G1 is a particularly important target of translational control pathways. Pharmacological inhibition of eIF4E-eIF4G1 binding impairs formation of memory for aversive Pavlovian conditioning as well as the accompa

SUBMITTER: Gindina S 

PROVIDER: S-EPMC8165027 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature