New Insights into Vaginal Environment During Pregnancy.

ABSTRACT: During pregnancy, the vaginal ecosystem undergoes marked changes, including a significant enrichment with Lactobacillus spp. and profound alterations in metabolic profiles. A deep comprehension of the vaginal environment may shed light on the physiology of pregnancy and may provide novel biomarkers to identify subjects at risk of complications (e.g., miscarriage, preterm birth). In this study, we characterized the vaginal ecosystem in Caucasian women with a normal pregnancy (n = 64) at three different gestational ages (i.e., first, second and third trimester) and in subjects (n = 10) suffering a spontaneous first trimester miscarriage. We assessed the vaginal bacterial composition (Nugent score), the vaginal metabolic profiles (¹H-NMR spectroscopy) and the vaginal levels

SUBMITTER: Marangoni A 

PROVIDER: S-EPMC8165225 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature