Lung volume reduction in emphysema: a pragmatic prospective cohort study.

ABSTRACT: Limited guidance exists for the implementation of lung volume reduction interventions in routine clinical care. We designed a pragmatic study to evaluate a strategy including endoscopic lung volume reduction (ELVR) and lung volume reduction surgery (LVRS) in heterogeneous emphysema. This prospective monocentre cohort study evaluated ELVR versus no-ELVR, followed by a cohort study evaluating LVRS. Primary outcome was the proportion of subjects with a forced expiratory volume in 1 s (FEV₁) improvement of ⩾100 mL at 3-month follow-up. Changes in FEV₁, residual volume (RV), 6-min walk distance (6MWD) and quality of life (St George's Respiratory Questionnaire (SGRQ)) were evaluated at 6-month follow-up. Hospital stay and treatment-related serious adverse events were

SUBMITTER: Dooms C 

PROVIDER: S-EPMC8165372 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature