Hepatic bile acid transport increases in the postprandial state: A functional ¹¹C-CSar PET/CT study in healthy humans.

ABSTRACT:

Background & aims

It is not known how hepatic bile acids transport kinetics changes postprandially in the intact liver. We used positron emission tomography (PET)/computed tomography (CT) with the tracer [N-methyl-¹¹C]cholylsarcosine (¹¹C-CSar), a synthetic sarcosine conjugate of cholic acid, to quantify fasting and postprandial hepatic bile acid transport kinetics in healthy human participants.

Methods

Six healthy human participants underwent dynamic liver ¹¹C-CSar PET/CT (60 min) during fasting and from 15 min after ingestion of a standard liquid meal. Hepatobiliary secretion kinetics of ¹¹C-CSar was calculated from PET data, blood samples (arterial and hepatic venous) and hepatic blood flow measured using indocyanine gree

SUBMITTER: Orntoft NW 

PROVIDER: S-EPMC8165435 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature