Feature Selection Methods for Protein Biomarker Discovery from Proteomics or Multiomics Data.

ABSTRACT: Untargeted mass spectrometry (MS)-based proteomics provides a powerful platform for protein biomarker discovery, but clinical translation depends on the selection of a small number of proteins for downstream verification and validation. Due to the small sample size of typical discovery studies, protein markers identified from discovery data may not be generalizable to independent datasets. In addition, a good protein marker identified using a discovery platform may be difficult to implement in verification and validation platforms. Moreover, although multiomics characterization is being increasingly used in discovery cohort studies, there is no existing method for multiomics-facilitated protein biomarker selection. Here, we present ProMS, a computational algorithm for protein marker select

SUBMITTER: Shi Z 

PROVIDER: S-EPMC8165452 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature