Tractography-Pathology Correlations in Traumatic Brain Injury: A TRACK-TBI Study.

ABSTRACT: Diffusion tractography magnetic resonance imaging (MRI) can infer changes in network connectivity in patients with traumatic brain injury (TBI), but the pathological substrates of disconnected tracts have not been well defined because of a lack of high-resolution imaging with histopathological validation. We developed an ex vivo MRI protocol to analyze tract terminations at 750-μm isotropic resolution, followed by histopathological evaluation of white matter pathology, and applied these methods to a 60-year-old man who died 26 days after TBI. Analysis of 74 cerebral hemispheric white matter regions revealed a heterogeneous distribution of tract disruptions. Associated histopathology identified variable white matter injury with patchy deposition of amyloid precursor protein (APP), lo

SUBMITTER: Nolan AL 

PROVIDER: S-EPMC8165468 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature