Maintenance therapy for untreated diffuse large B-cell lymphoma: a systematic review and network meta-analysis.

ABSTRACT:

Background

Several clinical trials have been conducted to evaluate the role of maintenance therapy in untreated diffuse large B-cell lymphoma (DLBCL) patients with complete response or partial response following standard immunochemotherapy; however, the effect of maintenance therapy remains uncertain, and a suitable maintenance strategy has not been determined because of the lack of direct/indirect comparisons.

Methods

We performed a systematic review and Bayesian network meta-analysis (NMA) to analyze and compare the effectiveness of different maintenance regimens in newly diagnosed DLBCL patients. We searched the PubMed Medline, Embase, Web of Science, Cochrane Database of Systematic Reviews, and Cochrane Central Register of Controlled Trials

SUBMITTER: Yuan T 

PROVIDER: S-EPMC8165531 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature