Relapse recovery in multiple sclerosis: Effect of treatment and contribution to long-term disability.

ABSTRACT:

Background

Although recovery from relapses in MS appears to contribute to disability, it has largely been ignored as a treatment endpoint and disability predictor.

Objective

To identify demographic and clinical predictors of relapse recovery in the first 3 years and examine its contribution to 10-year disability and MRI outcomes.

Methods

Relapse recovery was retrospectively assessed in 360 patients with MS using the return of the Expanded Disability Status Scale (EDSS), Functional System Scale and neurologic signs to baseline at least 6 months after onset. Univariate and multivariable models were used to associate recovery with demographic and clinical factors and predict 10-year outcomes.

Results

Recovery from relapses in the first 3 years was better in patien

SUBMITTER: Sotiropoulos MG 

PROVIDER: S-EPMC8165535 | biostudies-literature | 2021 Apr-Jun

REPOSITORIES: biostudies-literature