Deterioration of Avellino corneal dystrophy in a Chinese family after LASIK.

ABSTRACT:

Aim

To reveal the importance of TGFBI gene screening for candidates with a family history of corneal disease or granular opacities in corneal stroma before refractive surgery.

Methods

A 37-year-old male (proband) underwent bilateral laser-assisted in situ keratomileusis (LASIK) in 2002, with right vision decreased significantly in 2006. The proband and other 32 members of the family underwent a detailed ophthalmic examination, including vision acuity, intraocular pressure, slit-lamp photograph, fundus examination, optical coherence tomography (OCT) of cornea, and in vivo confocal microscope (IVCM) and peripheral blood was used for genomic DNA extraction. Seventeen TGFBI gene exons were analyzed via polymerase chain reaction amplification an

SUBMITTER: Jiang X 

PROVIDER: S-EPMC8165627 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature