Marine Sponge is a Promising Natural Source of Anti-SARS-CoV-2 Scaffold.

ABSTRACT: The current pandemic caused by SARS-CoV2 and named COVID-19 urgent the need for novel lead antiviral drugs. Recently, United States Food and Drug Administration (FDA) approved the use of remdesivir as anti-SARS-CoV-2. Remdesivir is a natural product-inspired nucleoside analogue with significant broad-spectrum antiviral activity. Nucleosides analogues from marine sponge including spongouridine and spongothymidine have been used as lead for the evolutionary synthesis of various antiviral drugs such as vidarabine and cytarabine. Furthermore, the marine sponge is a rich source of compounds with unique activities. Marine sponge produces classes of compounds that can inhibit the viral cysteine protease (M^pro) such as esculetin and ilimaquinone and human serine protease (TMPRSS2) such

SUBMITTER: Hamoda AM 

PROVIDER: S-EPMC8165660 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature