Spatio-spectral relationships between pathological neural dynamics and cognitive impairment along the Alzheimer's disease spectrum.

ABSTRACT:

Introduction

Numerous studies have described aberrant patterns of rhythmic neural activity in patients along the Alzheimer's disease (AD) spectrum, yet the relationships between these pathological features and cognitive decline are uncertain.

Methods

We acquired magnetoencephalography (MEG) data from 38 amyloid-PET biomarker-confirmed patients on the AD spectrum and a comparison group of biomarker-negative cognitively normal (CN) healthy adults, alongside an extensive neuropsychological battery.

Results

By modeling whole-brain rhythmic neural activity with an extensive neuropsychological profile in patients on the AD spectrum, we show that the spectral and spatial features of deviations from healthy adults in neural population-level activity inform their relevance to

SUBMITTER: Wiesman AI 

PROVIDER: S-EPMC8165730 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature