Identification of the prognostic value of ferroptosis-related gene signature in breast cancer patients.

ABSTRACT:

Background

Breast cancer (BRCA) is a malignant tumor with high morbidity and mortality, which is a threat to women's health worldwide. Ferroptosis is closely related to the occurrence and development of breast cancer. Here, we aimed to establish a ferroptosis-related prognostic gene signature for predicting patients' survival.

Methods

Gene expression profile and corresponding clinical information of patients from The Cancer Genome Atlas (TCGA) database and Gene Expression Omnibus (GEO) database. The Least absolute shrinkage and selection operator (LASSO)-penalized Cox regression analysis model was utilized to construct a multigene signature. The Kaplan-Meier (K-M) and Receiver Operating Characteristic (ROC) curves were plotted to validate the predictive effect of the prognos

SUBMITTER: Wang D 

PROVIDER: S-EPMC8165796 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature