Rabbit models of intracranial atherosclerotic disease for pathological validation of vessel wall MRI.

ABSTRACT:

Introduction

Vessel wall magnetic resonance imaging can improve the evaluation of intracranial atherosclerotic disease. However, pathological validation is needed to improve vessel wall magnetic resonance imaging techniques. Human pathology samples are not practical for such analysis, so an animal model is therefore needed.

Materials and methods

Watanabe heritable hyperlipidemic rabbits and apolipoprotein E knockout rabbits were evaluated against New Zealand white wild-type rabbits. Evaluation of intracranial arteries was performed with vessel wall magnetic resonance imaging and pathological analysis, rating the presence and severity of disease in each segment. Two-tailed t-tests were performed to compare disease occurrence and severity prevalence among rabbit subtype

SUBMITTER: McNally JS 

PROVIDER: S-EPMC8165905 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature