Altered lipid metabolism marks glioblastoma stem and non-stem cells in separate tumor niches.

ABSTRACT: Glioblastoma (GBM) displays marked cellular and metabolic heterogeneity that varies among cellular microenvironments within a tumor. Metabolic targeting has long been advocated as a therapy against many tumors including GBM, but how lipid metabolism is altered to suit different microenvironmental conditions and whether cancer stem cells (CSCs) have altered lipid metabolism are outstanding questions in the field. We interrogated gene expression in separate microenvironments of GBM organoid models that mimic the transition between nutrient-rich and nutrient-poor pseudopalisading/perinecrotic tumor zones using spatial-capture RNA-sequencing. We revealed a striking difference in lipid processing gene expression and total lipid content between diverse cell populations from the same patient, wit

SUBMITTER: Shakya S 

PROVIDER: S-EPMC8166002 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature