Longitudinal change in hippocampal and dorsal anterior insulae functional connectivity in subjective cognitive decline.

ABSTRACT:

Background

Subjective cognitive decline, perceived worsening of cognitive ability without apparent performance issues on clinical assessment, may be an important precursor to dementia. While previous cross-sectional research has demonstrated aberrant brain functional connectivity in subjective cognitive decline, longitudinal evaluation remains limited.

Methods

Here, we examined trajectories of functional connectivity over three measurement occasions ~18 months apart, using voxelwise latent growth models in cognitively unimpaired older adults with varying self-report of subjective cognitive decline (N = 69).

Results

We found that individuals who reported a greater degree of subjective cognitive decline showed a larger subsequent decrease in connectivity between compone

SUBMITTER: Viviano RP 

PROVIDER: S-EPMC8166120 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature