Ontology highlight
ABSTRACT:
SUBMITTER: Leach LL
PROVIDER: S-EPMC8166181 | biostudies-literature | 2021 May
REPOSITORIES: biostudies-literature
Leach Lyndsay L LL Hanovice Nicholas J NJ George Stephanie M SM Gabriel Ana E AE Gross Jeffrey M JM
Proceedings of the National Academy of Sciences of the United States of America 20210501 21
Loss of the retinal pigment epithelium (RPE) because of dysfunction or disease can lead to blindness in humans. Harnessing the intrinsic ability of the RPE to self-repair is an attractive therapeutic strategy; however, mammalian RPE is limited in its regenerative capacity. Zebrafish possess tremendous intrinsic regenerative potential in ocular tissues, including the RPE, but little is known about the mechanisms driving RPE regeneration. Here, utilizing transgenic and mutant zebrafish lines, phar ...[more]