Dataset Information

Angiotensin System Polymorphisms' in SARS-CoV-2 Positive Patients: Assessment Between Symptomatic and Asymptomatic Patients: A Pilot Study.

ABSTRACT:

Introduction

The renin-angiotensin-aldosterone system (RAAS), a metabolic cascade regulating pressure and circulating blood volume, has been considered the main system involved in the pathogenesis of severe lung injury and organs decline in COVID-19 patients. The angiotensin I-converting enzyme (ACE1), angiotensin-converting enzyme 2 (ACE2), angiotensinogen (AGT) and receptors angiotensin II receptor type 1 (AGTR1) are key factors for SARS-CoV-2 entering in the cells, sodium and water retention with an increase blood pressure, promotion of fibrotic and inflammatory phenomena resulting in a cytokine storm.

Methods

In this pilot study, the frequencies of six polymorphisms in the ACE1, ACE2, AGT and AGTR1 genes were analysed in symptomatic patients affected by COVID-19 and compared with the results obtained from asymptomatic subjects.

Results

Thus, we have identified that rs2074192 (ACE2), rs1799752 (ACE1) and rs699 (AGT) SNPs could potentially be a valuable tool for predicting the clinical outcome of SARS-CoV-2 infected patients. A genetic predisposition may be prospected for severe internal organ damages and poor prognosis in patients with COVID-19 disease, as observed in symptomatic vs asymptomatic.

Conclusion

This study provides evidence that analysis of RAAS polymorphisms could be considered the key point in understanding and predicting the SARS-CoV-2 course infection.

SUBMITTER: Cafiero C

PROVIDER: S-EPMC8166347 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature

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Publications

Angiotensin System Polymorphisms' in SARS-CoV-2 Positive Patients: Assessment Between Symptomatic and Asymptomatic Patients: A Pilot Study.

Cafiero Concetta C Rosapepe Felice F Palmirotta Raffaele R Re Agnese A Ottaiano Maria Pia MP Benincasa Giulio G Perone Romina R Varriale Elisa E D'Amato Gerardo G Cacciamani Andrea A Micera Alessandra A Pisconti Salvatore S

Pharmacogenomics and personalized medicine 20210527

<h4>Introduction</h4>The renin-angiotensin-aldosterone system (RAAS), a metabolic cascade regulating pressure and circulating blood volume, has been considered the main system involved in the pathogenesis of severe lung injury and organs decline in COVID-19 patients. The angiotensin I-converting enzyme (<i>ACE1</i>), angiotensin-converting enzyme 2 (<i>ACE2</i>), angiotensinogen (AGT) and receptors angiotensin II receptor type 1 (<i>AGTR1</i>) are key factors for SARS-CoV-2 entering in the cells ...[more]

PMID: 34079337

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Dataset Information

Angiotensin System Polymorphisms' in SARS-CoV-2 Positive Patients: Assessment Between Symptomatic and Asymptomatic Patients: A Pilot Study.

Introduction

Methods

Results

Conclusion

Publications

Angiotensin System Polymorphisms' in SARS-CoV-2 Positive Patients: Assessment Between Symptomatic and Asymptomatic Patients: A Pilot Study.

Similar Datasets

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