One Dose Versus Two Doses of Intravenous Tranexamic Acid in Total Joint Arthroplasty.

ABSTRACT:

Introduction

Despite its widespread use, a single formulation or dosing regimen of tranexamic acid (TXA) has not been universally agreed on for total joint arthroplasty. The purpose of this study is to compare previously uninvestigated single-dose and two-dose regimens in postoperative hemoglobin level and secondary outcomes within 30 days of surgery.

Methods

A retrospective search of our institution's database of patients who underwent primary total knee arthroplasty and primary total hip arthroplasty between January 1, 2017, and July 1, 2019, was performed. Patients were divided into two groups: one group received a 1-g bolus of intravenous TXA just before incision and another intravenous 1-g bolus during wound closure, and the second group received a single 1-g intravenou

SUBMITTER: Golz AG 

PROVIDER: S-EPMC8166358 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature